Project titles for:
Project titles for: 2008-10
- In silico analysis of Larger subunit of AGPase in Rice and Maize
- In silico Analysis of mutated in Larger subunit of AGPase in Maize
- Structural Comparison of Betaine Aldehyde Dehydrogenase-1 of Barley and Rice
- Analysis of Gene Expression Database of Skin Cancer
- Evaluation of Sequence Alignment Tools
- Phylogenetic analysis of Drb 3.2 gene
- Modelling of Smaller subunit of AGPase in Rice and Maize
- Prediction of Protein structure from sequence
- Development of Clinical Information Database of domestic animals
- To identify distant relationship between flavoprotein superfamily
- Promoters comparison in bacteria
- Transport protein features analysis
- Genome deciphering and comparative genomics of Solanaceous genome
- Computational approach in deciphering effect of gene alteration in Arabidopsis Thaliana
- Simulation of conformational changes in protein
Among proteins, transport proteins are very important because they play main role in field of pharmacology, toxicology. The objective of present work was to analyze features of transport protein. It is a core problem in computational biology because of limited number of tools and complex nature of transport proteins. Tools are versatile and extensible integrated bioinformatics toolkit for the analysis of biological sequences over the Internet. Transport protein have 9 classes from which 6th and 7th classes are undefined and 27 subclasses One protein from each family were taken and analyze their features. Features typically imply architecture which in turn may imply structural and functional information. Proteins used in this study were transport proteins like amtB, FAT1 VLYS aka S, Synaptobrevin- 2 aka VAMP-2, Hem_agglutinin, Cldn7, Irt1 aka T16H5.50 DCOA aka OADA1 aka OADA aka STM0055 aka OADA2 akaSTM3352 aka AT4G19690, Tat proteins, HasB, UgpA aka B3452, Mtr UCRI aka PETA A, Green-light absorbing proteorhodopsin [Precursor], PTHA aka SRLB aka GUTB aka B2704, Putative integral membrane protein, Fat1 aka YBR041W aka YBR0411 DsbD aka NMA1719, Cytochrome b561, EmrA aka B2685, Hainantoxin- RLIP764, Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2 precursor, of nine protein classes. All the sequences of proteins were downloaded from TCDB database. These classes have wide applications in human biology. Methods used for this study was based on HMMs and kyte dollite index for the purpose of features prediction. Different tools are used like octopus, rhythm etc based on HMMs were found better identifier. Features of transport proteins are different from others in many ways. Transmembrane region is main feature of all because it shows the occurrence of transport proteins and transmembrane segment. The discovery of an orientation between residues of proteins is frequently used, therefore, to justify a common functional role in disease.