Project titles for:
Project titles for: 2005-07
- Virtual Screening for Inhibitors against NS3 protease of dengue virus
- Virtual Screening of Tuberculosis Inhibitors
- Determination of Sequence Homology in Promoter region of drought and salt responsive genes in rice and/or cereals
- Designing of Nanobody against Dandruff which works under harsh conditions
- In silico Designing of Clinically Robust VHH antibody Against Rotavirus
- Phylogenetic Analysis of Bluetongue Virus using VP2 and VP7 genes
- Phylogenetic Analysis of Rotavirus using VP4 and VP7 gene segments
- Pharmacophore based Screening of HIV I Reverse Transcriptase Inhibitors
- Rice Genome Search for BAD -2 Homologous genes
- Putative functional annotation of genes near BAD-2 locus of rice chromosome 8
- Bioinformatics Web Tools
Homology searches really meant to those "similarity” which arises due to inheritance from a common ancestor". Computationally homology was determined by using various alignment programs- BLAST, FASTA, PSIBLAST, CLUSTALX, TREE VIEWER, and CLUSTALW. Homology search tools showed that BAD-2 gene (chromosome 8) is homologous to BAD-1 (chromosome 4) across the rice genome. Multiple alignment of amino acid sequence of BAD-2 (fgr), BAD-2 (non fragrant) and BAD-1 showed some sequences which are highly conserved in BAD-1 and BAD-2 ( non fragrant) and these sequences are believed to be required for functional activity. These conserved regions were absent from the truncated version present in fragrant rice varities. Analysis of sequences in genes from other crops showed that same type of BADs from different crops were more closely related than different BADs from the same species. This may infer a distinct and important role for each of the two BADs separately.